Metformin minor nifedipine may increase the plasma metformin cmax and auc and increase the amount of metformin excreted in the urine.
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metformin, with a much shorter action time than phenformin, has a much lower risk for severe side effects and is quite safe for use by anyone who is otherwise healthy.
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the diabetes prevention program dpp investigated the value of intensive lifestyle intervention diet and exercise or metformin in delaying or preventing type 2 diabetes in high-risk individuals with impaired glucose tolerance, a precursor to full-blown diabetes.
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in a double-blind clinical study of metformin in patients with type 2 diabetes, a total of 141 patients received metformin therapy up to 2550 mg per day and 145 patients received placebo.
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